In order to further secure access to my workstation, after the switch to Gentoo sources, I now enabled two-factor authentication through my Yubico U2F USB device. Well, at least for local access - remote access through SSH requires both userid/password as well as the correct SSH key, by chaining authentication methods in OpenSSH.
Enabling U2F on (Gentoo) Linux is fairly easy. The various guides online which talk
pam_u2f setup are indeed correct that it is fairly simple. For completeness
sake, I've documented what I know on the Gentoo Wiki, as the pam_u2f article.
I administer a couple of systems which provide interactive access by end users, and for this interactive access I position OpenSSH. However, I also use this for administrative access to the system, and I tend to have harder security requirements for OpenSSH than most users do.
For instance, on one system, end users with a userid + password use the sFTP server for publishing static websites. Other access is prohibited, so I really like this OpenSSH configuration to use chrooted users, internal sftp support, whereas a different OpenSSH is used for administrative access (which is only accessible by myself and some trusted parties).